The effect of barbiturates on the metabolism of phenytoin appears to be variable. Some investigators report an accelerating effect, while others report no effect. Because the effect of barbiturates on the metabolism of phenytoin is not predictable, phenytoin and barbiturate blood levels should be monitored more frequently if these drugs are given concurrently.
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Barbiturates appear to enhance the metabolism of exogenous corticosteroids probably through the induction of hepatic microsomal enzymes. Patients stabilized on corticosteroid therapy may require dosage adjustments if barbiturates are added to or withdrawn from their dosage regimen.
Has been used for routine sedation. However, barbiturates used infrequently for this indication since there are few clinical situations Sopra which oral barbiturates provide a safety or efficacy advantage over nonbarbiturate sedatives/hypnotics.
Pentobarbital belongs to the barbiturate class of medications and primarily works primarily on the central nervous system (CNS).
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Variable; patient-dependent and may vary occasionally within same patient. About 15 minutes following IV administration.
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Breastfeeding considerations: Per breastfeeding considerations, it should be noted that barbiturates are present Durante breast milk.
Monitoring maternal blood levels for fetal safety Durante any pregnant patient taking these drugs is essential.
Additionally, it is used for the short-term treatment of insomnia and as a pre-anesthetic Con the operating room. Pentobarbital has also been used to induce coma Per individuals with cerebral ischemia and to lower intracranial pressure Durante situations like Reye’s syndrome and traumatic brain injury.
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Based on comparisons across species, the window of vulnerability to these changes is believed to correlate with exposures Per the third trimester through the first several months of life, but may extend out to approximately 3 years of age Con humans.
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